In Central Europe, the clinical application of a mixture of ozone and oxygen gas in the treatment of chronic viral infections, ischemia and cancer was initiated in Germany and Austria in the early 1950s. A main effect of ozone gas application is the induction and release of several cytokines, including IFN-alpha, IL-1 beta, IL-2, IL-4, IL-6, IL-10, IL-12, TNF-alpha, GMCSF and TGF-beta1 and endorphins. Thus, it is strongly suggested, that ozone gas has first of all immune modulating effects, and that it’s possible anti-tumour and anti-viral activities can be explained in this way.
In addition, ozone gas application has been associated with improved wound healing (ulcus crusis and decubitus) and blood perfusion, and with prevention and improvement of degeneration of the macula of the retina in the elderly. The routine procedure is to take 50 to 300 ml peripheral blood from the patient and, in vitro; to expose the whole blood to a determined abounds of ozone gas. Within minutes the blood is re-infused into the patient. Own Blood Therapy is tolerated very well and usually patients document feelings of well-being and sometimes euphoria right after the treatment. This phenomenon could be explained by the induction and release of endorphins.
Technical Data Ozone Therapy HYPER-MEDOZEN COMFORT
Input voltage: 230V, 50 Hz
Input power: 210 VA
Ozone generator: quartz-controlled, frequency 1 kHz
Dimensions:Concentration; 10-80 ug/ml
Control of concentration: +-10% bell Signal if concentration drop or exceeded
Flow rate: approx. 1.2 litres per minutes
Permanent connection: ure-connection, automatic timing 20 min.
Safety off: Ultrasonic detector with crimp valve and pressure relief
Attention!: Only use med. oxygen via depressurizes 3,5 l/min
Ozone Therapy
Ozone is a chemical compound consisting of three oxygen atoms O3 (ie triatomic oxygen), a highly energetic form of normal (diatomic) atmospheric oxygen (O2). Thus, the molecules of these two forms are different in structure, ie:
Medical ozone is always a mixture of purest ozone and purest oxygen. Medical ozone has highly pronounced bactericidal, fungicidal and virostatic properties, and is thus widely used in disinfecting infected wounds, as well as in bacterially and virally produced diseases. Its ability to stimulate the circulation is used in the treatment of circulatory disorders and makes it valuable in revitalizing organic functions.
When administered at low concentrations, the organisms own resistance is mobilized, ie ozone (re)activates the immune system. As a response to this activation through ozone, the body's immune cells produce special messengers called cytokines (including important mediators such as interferon’s or interleukins). These inform other immune cells, setting off a cascade of positive changes throughout the immune system, which is stimulated to resist diseases for example. This means that the application of medical ozone is extremely useful for immune activation in patients with a low immune status and/or immune deficit. Small quantities of ozone applied in what is called “major autohemotherapy” (external treatment of the patient's blood before re-infusion) consequently activate the body's own antioxidants and radical scavengers. It is thus possible to understand why ozone is used in diseases which involve chronic inflammation.
Indications
Thanks to its selective properties, medical ozone is used in three principal fields of indication:
circulatory disorders
diseases produced by viruses such as liver diseases (hepatitis) and herpes
infected, badly healing wounds and inflammatory processes, such as for example
Open ulcers on the legs (ulcus cruris)
Inflammatory intestinal conditions (Colitis, Proctitis),
Burns, scalds and infected wounds, fungus infections and others
As an additive or complementary therapy in various types of cancer, ozone is applied for general immunoactivation at low dosages in the form of "major autohemotherapy" (re-infusion) or "minor autohemotherapy" (re-injection) via the intramuscular route.
Kinds/Forms of application
Many decades of experience and a number of recent clinical studies have shown that the following five application methods are valid for ozone:
Major Autohemotherapy – LOT - (treatment of the patient's blood outside the body before re-infusion) in geriatrics (age-related conditions), for revitalization, in the treatment of circulatory disorders and virus-produced diseases, and for general immunoactivation.
By this method, 100 to 200 ml of the patient's own blood is withdrawn in the normal manner, enriched externally with an exactly defined quantity of ozone (with disposable sterile material and containers!). The ozone reacts completely - ie at a rate of 100 % - with specific substances making up the red and white blood cells and thereby activates their vital activities = metabolism. It is this activated blood (not ozone or oxygen!) that is immediately reintroduced into the patient's system using a normal drip unit.
Using the same principle, minor Autohemotherapy – SOT - is an application, via the intramuscular route, of O3 treated blood for unspecific immunoactivation revitalization: it can be used in allergic diseases or in a general way to improve the body's inherent resistance.
External treatment is primarily achieved through a closed system using O3 gas fed into special plastic “boots” (for the legs and feet) or bags, foils etc fitting various parts of the body. These are of course made of ozone-resistant materials. The parts of the body treated have previously been moistened with water, as ozone cannot act on dry areas. This method is highly effective in treating ulcers, sores, open wounds, postoperative lesions, shingles (herpes) and infected areas etc. Other forms are ozonized pure water (eg in dental treatments) and ozonized pure medical olive oil (for skin eruptions such as eczemas and conditions involving molds, funguses and lichens etc).
O3 gas application via the rectal route is not as inconvenient or unpleasant as it sounds (medically, it is called Insufflation). In fact, the patient feels absolutely nothing, as the O3 gas is directly absorbed by the sensitive intestinal membranes; in addition, the specially designed disposable tube is lubricated, which makes the method totally hygienic - and practical, as a patient can apply it himself/herself. This method is primarily indicated for inflammatory conditions of the intestinal tract, but is finding increasing use for general revitalization processes.
In what diseases is ozone therapy usually applied?
A whole number of pathological conditions exist which can be influenced positively or even healed by ozone. This is a fact which has been confirmed by a wide series of scientific investigations and medical publications. As a rule, medical ozone is applied in addition to other therapeutic methods ie it belongs to the field of complementary medicine.
Malignant disease (cancer)
Ozone-autohaemotransfusion can be applied with great profit in the form of an additional, biological, therapy in malignant conditions. We here make use of ozone's immunoactivating property, produced when it is applied at a low dose. Immune cells - such as lymphocytes, helper and suppressor cells, and natural killer cells - are activated via biological reactions induced by ozone to respond by producing messenger proteins called cytokines to which, for example, the interferons belong. In fact, ozone makes the body produces increased quantities of its own interferon’s and interleukins. On reintroduction of the ozonized blood, a cascade of positive immune reactions is set off, also contributing to general resistance and wellbeing.
Circulatory disorders
Arterial circulatory disorders, for which, among other symptoms, a feeling of coldness in the legs or pains after walking only short distances ("short cut" syndrome) are alarming signs, have been a classical indication for ozone therapy for over 40 years now. Its success has been confirmed by a large number of clinical trials. Ozone is applied as a complement to and in combination with other methods in classical and complementary medicine.
Regeneration and revitalisation
Stress situations on the job or conditions of excessive mental and physical tension respond particularly well to O3 application. Its ability to activate red and white blood cell metabolism produces an improvement in general wellbeing, and brings about a general revitalisation. Professional sportsmen and -women profit greatly from this fact as well. Although ozone does not give its user a higher performance level, it does improve physical output during the endurance phase, ie just below maximum exertion. In addition, the regeneration phase is measurably shortened in endurance sports.
The elderly patient. - Prevention and therapy
Elderly patients respond very well to medical ozone therapy, as it is here possible to make use of all its clinical advantages, such as that of making an improved supply of oxygen accessible to all tissues, mobilizing the immune system, and activating the body's own supply of antioxidants and radical scavengers. Furthermore, we have its positive influence in cerebral circulatory disorders - a condition characterized by a general reduction in physical performance, insecurity in walking, and feelings of dizziness. In addition to other measures applied in complementary medicine, medical ozone is also used as a preventive, contributing to a marked increase in life quality.
Diseases of the eye
Circulatory disturbances due to old age also affect the eye with atrophic and degenerative changes. For example, senile macular degeneration is well known, occurring at the center of the retina - the point where visual focus is at its sharpest. Its sequels are thus able to influence the optic nerve to varying degrees, producing what is called optic nerve atrophy. Results obtained from a clinical trial carried out at the University of Siena show, in addition to reports from practical applications, improvements in vision lasting for 6 to 8 months after ozone- autohaemotransfusion. Continuing the series of treatments can produce further improvement in visual performance or prevent it from worsening.
Fungal skin infections and infected skin lesions
The fungicidal and bactericidal properties of ozone have been successfully in use for over 100 years in the treatment of water for drinking. They make medical ozone an effective therapeutic agent in combating persistent skin moulds and fungi, especially those of the feet with bacterial infections, fungal infections of the trunk or against fungal/mycotic infections of the mucous membranes.
Infected wounds
The local treatment of infected wounds, such as may easily occur with open bed sores (decubitus), ulcers of the lower leg (ulcus cruris), diabetic gangrene or delayed/disturbed wound healing processes, belong to the classical application fields of medical ozone. We here primarily make use of its disinfectant, ie bactericidal and fungicidal, effects, to obtain a germ-free and clean wound. Once this has been achieved, we then apply lower doses of O3 gas to accelerate/improve wound healing.
Intestinal diseases: proctitis and colitis
In the case of inflammatory intestinal processes, particularly during their early stages, the local application of ozone in the form of rectal O3 gas insufflation has been proved very useful. A series of 10 ozone applications is sufficient in most cases. Several such series are only necessary in about 10 % of the patients (from a proctitic clinical study on O3 involving 248 patients).
Viral diseases
Herpes simplex (facial herpes), herpes zoster (shingles)
Both types of herpes are caused by viruses. Herpes of the lips (H. labialis), a frequently recurring condition and a highly unpleasant disease, can be treated very successfully with ozone in combination with other medical methods.
In the case of herpes zoster or shingles, the complementary application of ozone is useful, both in the form of ozonized water compresses and O3 autohaemotransfusions.
Inflammatory processes of the liver
Inflammatory diseases of the liver are counted among the classical indications for medical ozone. Whereas the treatment of hepatitis A (HVA = hepatitis virus A) is relatively unproblematic and produces complete healing, another form, hepatitis B (HVB = hepatitis virus B), frequently takes a chronic course. Here, in addition to classical medical treatment methods, we find that ozone autohaemotransfusion or the rectal insufflation of controlled ozone/oxygen gas quantities can be successful. This also applies to the treatment of hepatitis C which, due to an incubation period capable of lasting for a number of years, is generally not diagnosed as a liver disease until it has become a chronic condition.
Inflammatory and degenerative joint conditions
When we divide inflammatory diseases of the joints into three phases, it is particularly stages 1 and 2, ie those not yet involving a severe bone deformation, that are responsive to medical ozone application. This applies to gonarthritis (inflammation of the knee joint) or the active arthritic form in knee and shoulder joints. Here, intraarticular ozone injections applied in addition to basic standard medical methods - in this case specific exercise therapy measures - are of great use. We here make full use of the antiinflammatory effects of ozone, in addition to its immunomodulatory properties and its ability to activate cartilage metabolism.
Arthritic/rheumatic conditions, chronic Polyarthritis
The term arthritic/rheumatic conditions includes various painful diseases of the skeletal or muscular system, partly also involving functional restrictions. In general, the application of medical ozone can here be regarded as being a complementary measure only, combined with a basic classical method and corresponding physiotherapy. In the case of rheumatic arthritis (chronic Polyarthritis), our experience shows that ozone autohaemotherapy is a very useful complementary form when given during the non-acute phases. Its immunomodulatory and antiinflammatory properties are here its basic principle of action.
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